PROTECTIVE ROLE OF VITAMIN E AND VITAMIN C ON MORPHOLOGY OF GASTRIC MUCOSAL INJURY INDUCED BY ASPIRIN IN ALBINO RATS

Background: Peptic ulcer has become an immense problem in our health care system. One of the major cause being overuse NSAIDs Pakistan.
 Objective: To evaluate gastro protection by Vitamin E, C and combination E on morphology aspirin induced gastric mucosal injury albino rats.
 Methodology: 45 adult rats were taken organized into 5 groups. Control was formed Group I. II given aspirin. III IV V received C, All doses for 14 days. Rats then sacrificed after 24 hours their stomachs examined to compare gross histological findings regarding colour mucosa, presence ulcer, site epithelial integrity extent ulcer.
 Results: Increased frequency ulcers extending submucosa found group as compared rest The that along with showed significantly better condition than all groups showing normal mucosa intact epithelium most animals.
 Conclusion: Combination greater defensive effect insult or alone reduction severity ulcer.